Morpholine → 4-(5-Iodopyrimidin-2-yl)morpholine
反応式
Cl[C:2]1[N:7]=[CH:6][C:5]([I:8])=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[I:8][C:5]1[CH:4]=[N:3][C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[N:7][CH:6]=1参加物
3
実験手順
The mixture of 2-chloro-5-iodopyrimidine (0.200 g, 0.836 mmol) in morpholine (3.0 mL) was refluxed for 2-3 h. The reaction mass was quenched in water and the solid obtained was filtered off. The obtained solid was dried to afford 0.180 g of the desired product. 1H NMR (300 MHz, DMSO d6): δ 3.63 (s, 8H), 8.52 (s, 2H); MS (m/z): 292.25 (M+H)+.
後処理
- temperaturewas refluxed for 2-3 h
- customThe reaction mass was quenched in water
- customthe solid obtained
- filtrationwas filtered off
- customThe obtained solid was dried
出典と根拠
- ORDレコード
- ord-2a41b118cb804d26bdcf752d9a382063
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09439890B2
反応ノート
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