Sulfuric Acid → 2-Chloro-6-fluorobenzamide

HRID 59235ノート

反応式

HRID 59235 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:12]>>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[C:4]([NH2:5])=[O:12]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 695872-Chloro-6-fluorobenzonitrile

生成物 1

HCID 985642-Chloro-6-fluorobenzamide

実験手順

A solution of 2-chloro-6-fluorobenzonitrile (8.0 g, 51.61 mmol) in conc. sulphuric acid (50 mL) was heated at 60-70° C. for 6-7 h. The reaction mass was quenched in water and extracted with DCM. The organic layer was dried over anhydrous sodium sulphate and concentrated to afford 5.5 g of desired product.

後処理

  1. customThe reaction mass was quenched in water
  2. extractionextracted with DCM
  3. dry with materialThe organic layer was dried over anhydrous sodium sulphate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-b073ea0b37854f5bad6f0a9176e3e856
出典データセット
uspto-grants-2016_09
特許番号
US09439890B2

反応ノート

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