Hydrochloric Acid → Methyl 5-hydrazinyl-2-methoxybenzoate

HRID 59243

反応式

HRID 59243 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[N:14]([O-])=O.[Na+].Cl>O>[NH:1]([C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8])[NH2:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 89843Methyl 5-amino-o-anisateHCID 23668193Sodium Nitrite

生成物 1

HCID 55281102Methyl 5-hydrazinyl-2-methoxybenzoate収率 78,411.602%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The title compound was prepared according to the procedure described in step-2 of Intermediate-7 by using methyl 5-amino-2-methoxybenzoate (15.0 g, 0.082 mol), stannous chloride (37.25 g, 0.16 mmol), sodium nitrite (6.28 g, 0.091 mmol), conc. HCl (400 mL) and water (100 mL) to afford 14.0 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 3.75 (s, 6H), 7.09 (m, 1H), 7.20-7.23 (m, 1H), 7.34 (s, 1H), 10.20 (br s, 2H); MS (m/z): 197.27 (M+H)+.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-f46810f5640e46409118d4df62bc83ab
出典データセット
uspto-grants-2016_09
特許番号
US09439890B2

関連ノート

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