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Boron trifluoride → 1-(4-(Trifluoromethyl)phenyl)cyclopropanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Boron trifluoride | HCID 6356 | — |
| 反応物 | Benzonitrile, 4-(trifluoromethyl)- | HCID 67995 | — |
| 反応物 | HCID 178418443 | HCID 178418443 | — |
| 触媒 | Titanium isopropoxide | HCID 11026 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-(4-(Trifluoromethyl)phenyl)cyclopropanamine | HCID 53420453 | 180% |
反応手順
The title compound was prepared according to the procedure described in Intermediate-12 by using of 4-(trifluoromethyl)benzonitrile (1.0 g, 0.58 mmol), diethyl ether (20 mL), titanium isopropoxide (2.0 g, 0.70 mmol), ethyl magnesium bromide (4.30 mL, 12.86 mmol) and boron trifluoride solution (1.5 mL) to afford 0.210 g of desired product. 1H NMR (CDCl3): δ 1.05 (s, 2H), 1.60 (s, 2H), 1.78 (s, 2H), 7.36 (d, J=7.8 Hz, 2H), 7.55 (d, J=8.1 Hz, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09439890B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-1907ea81c3484ddbbe15735aea810ce6 |
| 出典メモ | uspto-grants-2016_09 |