5-Chloro-2-nitropyridine → 5-(Methylthio)-2-nitropyridine

HRID 592587ノート

反応式

HRID 592587 の反応式
Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:8]([O-:10])=[O:9])=[N:6][CH:7]=1.[CH3:11][S-:12].[Na+]>CO>[CH3:11][S:12][C:2]1[CH:3]=[CH:4][C:5]([N+:8]([O-:10])=[O:9])=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 2598065-Chloro-2-nitropyridineHCID 4378561Sodium methanethiolate

生成物 1

HCID 220361825-(Methylthio)-2-nitropyridine収率 66%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
20 °C

実験手順

To a mixture of 5-chloro-2-nitropyridine (3 g, 18 mmol) in MeOH (20 mL), sodium methanethiolate (1.4 g, 20 mmol) was added at 0° C. and the mixture stirred at 20° C. for 2 hours. The resulting suspension was filtered and washed with water, and dried in vacuum to afford crude 117a as a yellow solid (2 g, 66%) without purification for next step. MS: [M+H]+ 171.

後処理

  1. additionwas added at 0° C.
  2. filtrationThe resulting suspension was filtered
  3. washwashed with water
  4. customdried in vacuum

出典と根拠

ORDレコード
ord-2f39e386986a480a9d1112ecaf13a240
出典データセット
uspto-grants-2016_01
特許番号
US09238655B2

反応ノート

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