Hydrochloric Acid → HCID 86684611、化合物
反応式
[CH3:1][N:2]1[CH:6]=[C:5]([NH:7]C(=O)OC(C)(C)C)[N:4]=[C:3]1[CH3:15].[ClH:16]>ClCCl.O1CCOCC1>[ClH:16].[CH3:1][N:2]1[CH:6]=[C:5]([NH2:7])[N:4]=[C:3]1[CH3:15]参加物
5
実験手順
To a solution of 337b (1.2 g, 5.68 mmol) in dichloromethane (5.0 mL) was added 3M HCl in dioxane (5.0 mL). This mixture was stirred at room temperature for 4 h and concentrated under reduced pressure. The crude product was washed by ethyl acetate to afford 337c (450 mg, 55%) as a pale yellow solid, which was used in the next step without further purification. MS-ESI: [M+H]+ 112.2
後処理
- concentrationconcentrated under reduced pressure
- washThe crude product was washed by ethyl acetate
出典と根拠
- ORDレコード
- ord-9e6b97a1dce5428b893ea37841dfe394
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09238655B2
反応ノート
読み込み中…