関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl Salicylate | HCID 4133 | — |
| 反応物 | Propylamine | HCID 7852 | — |
| 生成物 | N-Propylsalicylamide | HCID 81966 | 84% |
反応手順
The crude methyl 2-hydroxybenzoate was dissolved in n-propylamine (400 mL). The reaction mixture in a sealed reactor was stirred at 80° C. overnight. The reaction mixture was concentrated under reduced pressure to give the crude material that was purified by silica gel flash column chromatography to afford 120 g (84%) of 2-hydroxy-N-propylbenzamide. LCMS ESI (+) m/z 180 (M+1) detected.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09242964B2 |
|---|
| 出典データセット | uspto-grants-2016_01 |
|---|
| ORD ID | ord-4bf1486374c54440889cb13a2d5c8637 |
|---|
| 出典メモ | uspto-grants-2016_01 |
|---|
