Hydrochloric Acid → 3-ethyl-2-pyridin-3-yl-1H-indole

HRID 593509

反応式

HRID 593509 の反応式
[C:1]1([NH:7]N)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15](=O)[CH2:16][CH2:17][CH3:18])[CH:10]=1.Cl>CCO>[CH2:17]([C:16]1[C:6]2[C:1](=[CH:2][CH:3]=[CH:4][CH:5]=2)[NH:7][C:15]=1[C:11]1[CH:10]=[N:9][CH:14]=[CH:13][CH:12]=1)[CH3:18]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 7516PhenylhydrazineHCID 4595021-(Pyridin-3-yl)butan-1-one

生成物 1

HCID 582156283-ethyl-2-pyridin-3-yl-1H-indole

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A flask is charged with phenylhydrazine (0.873 g, 6.46 mmol) and EtOH (14 mL). 1-Pyridin-3-yl-butan-1-one (0.914 g, 6.13 mmol) is added and the reaction is refluxed for 1 h. After cooling to room temperature, HCl (4M in 1,4-dioxane, 6.45 mL, 25.83 mmol) is added. The reaction mixture is refluxed for 4 h. After cooling to room temperature, the precipitate formed is filtered to afford 3-ethyl-2-pyridin-3-yl-1H-indole as a yellow solid. MS (ESI) m/z 223.0 (M+H)+.

後処理

  1. temperaturethe reaction is refluxed for 1 h
  2. temperatureThe reaction mixture is refluxed for 4 h
  3. temperatureAfter cooling to room temperature
  4. customthe precipitate formed
  5. filtrationis filtered

出典と根拠

ORDレコード
ord-7231d6a439804990987645806434c42f
出典データセット
uspto-grants-2016_01
特許番号
US09242963B2

関連ノート

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