化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 5((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid | HCID 89736668 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzamide | HCID 90019517 | — |
反応手順
The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid (1.0 g), oxalyl chloride (1.0 mL), THF (50 mL) and ammonia gas to afford 0.800 g of the desired product. 1H NMR (400 MHz, DMSO d6): δ 4.53 (m, 2H), 7.43 (m, 1H) 7.44 (m, 2H), 7.48 (m, 1H), 10.0 (br s, 1H)); MS (m/z): 297.10 (M−H)−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09439890B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-4d6561c410114ef5a3525abf089e6be1 |
| 出典メモ | uspto-grants-2016_09 |