Ammonia → 5((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzamide

HRID 59360

反応式

HRID 59360 の反応式
[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][CH2:6][C:7]1[C:8]([F:17])=[CH:9][C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12](O)=[O:13])=[O:4].C(Cl)(=O)C(Cl)=O.[NH3:26]>C1COCC1>[F:1][C:2]([F:19])([F:18])[C:3]([NH:5][CH2:6][C:7]1[C:8]([F:17])=[CH:9][C:10]([Cl:16])=[C:11]([CH:15]=1)[C:12]([NH2:26])=[O:13])=[O:4]

参加物

5

反応物 3

HCID 222AmmoniaHCID 65578Oxalyl chlorideHCID 897366685-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid

生成物 1

HCID 900195175((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid (1.0 g), oxalyl chloride (1.0 mL), THF (50 mL) and ammonia gas to afford 0.800 g of the desired product. 1H NMR (400 MHz, DMSO d6): δ 4.53 (m, 2H), 7.43 (m, 1H) 7.44 (m, 2H), 7.48 (m, 1H), 10.0 (br s, 1H)); MS (m/z): 297.10 (M−H)−.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-4d6561c410114ef5a3525abf089e6be1
出典データセット
uspto-grants-2016_09
特許番号
US09439890B2

関連ノート

読み込み中…