Stannous chloride dihydrate → N-(4-chloro-2-fluoro-5-hydrazinylbenzyl)-2,2,2-trifluoroacetamide
反応式
[NH2:1][C:2]1[C:3]([Cl:17])=[CH:4][C:5]([F:16])=[C:6]([CH:15]=1)[CH2:7][NH:8][C:9](=[O:14])[C:10]([F:13])([F:12])[F:11].[N:18]([O-])=O.[Na+].O.O.Cl[Sn]Cl>Cl>[Cl:17][C:3]1[C:2]([NH:1][NH2:18])=[CH:15][C:6]([CH2:7][NH:8][C:9](=[O:14])[C:10]([F:11])([F:12])[F:13])=[C:5]([F:16])[CH:4]=1参加物
5
実験手順
The title compound was prepared according to the procedure described in step-1 of Intermediate-61 by using N-(5-amino-4-chloro-2-fluorobenzyl)-2,2,2-trifluoroacetamide (2.0 g, 0.007 mmol), NaNO2 (0.612 g, 0.008 mmol), SnCl2.2H2O (4.10 g, 0.018 mmol), and conc. HCl (100 mL) to afford 1.0 g of the desired product.
後処理
- customThe title compound was prepared
出典と根拠
- ORDレコード
- ord-faccaa875f544aa4996a1b4c550b1e8f
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09439890B2
反応ノート
読み込み中…