関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-(4,6-Dichloropyrimidin-2-yl)morpholine | HCID 2772068 | — |
| 反応物 | 2,2-Dimethylmorpholine | HCID 18959674 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(6-Chloro-2-morpholinopyrimidin-4-yl)-2,2-dimethylmorpholine | HCID 90409549 | — |
反応手順
A mixture of 2,2-dimethylmorpholine (2.0 equiv.), 4-(4,6-dichloropyrimidin-2-yl)morpholine (1 equiv.) and triethylamine (6 equiv.) in EtOH (0.2 M) were heated to 110° C. for 25 min in the microwave. The reaction mixture was partitioned between EtOAc and water. The organic phase was dried over sodium sulfate. The resulting solution was concentrated and dried under vacuo to give 4-(6-chloro-2-morpholinopyrimidin-4-yl)-2,2-dimethylmorpholine and was used in the next step without further purification. LCMS (m/z) (M+H)=313.2, Rt=0.86 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09242969B2 |
|---|
| 出典データセット | uspto-grants-2016_01 |
|---|
| ORD ID | ord-4511474057dd4666a0129689127ff48e |
|---|
| 出典メモ | uspto-grants-2016_01 |
|---|
