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3-bromo-4-(hydroxymethyl)-N-(3-(trifluoromethyl)phenyl)benzamide → 3-bromo-4-formyl-N-(3-(trifluoromethyl)phenyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-bromo-4-(hydroxymethyl)-N-(3-(trifluoromethyl)phenyl)benzamide | HCID 90407963 | — |
| 触媒 | Manganese dioxide | HCID 14801 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-bromo-4-formyl-N-(3-(trifluoromethyl)phenyl)benzamide | HCID 90408797 | 100% |
反応手順
MnO2 (8.0 equiv.) was added into a solution of 3-bromo-4-(hydroxymethyl)-N-(3-(trifluoromethyl)phenyl)benzamide (1.0 equiv.) in DCM (0.14 M). The suspension was stirred at rt for 1 hr. The mixture was filtered over celite and concentrated to yield 3-bromo-4-formyl-N-(3-(trifluoromethyl)phenyl)benzamide in 100% yield. LC/MS (m/z)=373.9 (MH+), Rt=0.0.94 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09242969B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-4e48c0fa86af45f8b79503bd0b7583b0 |
| 出典メモ | uspto-grants-2016_01 |