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3-Quinolinecarboxaldehyde → 6-(2,6-Dimethoxyphenyl)-1-(quinolin-3-ylmethyl)piperidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Quinolinecarboxaldehyde | HCID 83641 | — |
| 反応物 | Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate | HCID 69082713 | — |
| 生成物 | 6-(2,6-Dimethoxyphenyl)-1-(quinolin-3-ylmethyl)piperidin-2-one | HCID 69084152 | — |
反応手順
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with commercially available quinoline-3-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions B): tR=0.68 min.; [M+H]+: 377.36 g/mol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09242970B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-77b80e1e5ff3457d9dcef04ad41415f9 |
| 出典メモ | uspto-grants-2016_01 |