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HRID 594423作成日：2026年10月26日

Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate → 1-((5-Chloro-6-(difluoromethoxy)pyridin-3-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

https://huagongshe.com/reaction/594423

反応式

関与物質

役割名称HCID仕込み量
反応物Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoateHCID 69082713—
反応物3-Pyridinecarboxaldehyde, 5-chloro-6-(difluoromethoxy)-HCID 86695614—
生成物1-((5-Chloro-6-(difluoromethoxy)pyridin-3-yl)methyl)-6-(2,6-dimethoxyphenyl)piperidin-2-oneHCID 69081953—

反応手順

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with 5-chloro-6-(difluoromethoxy)-nicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.88 min.; [M+H]+: 427.28 g/mol.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09242970B2
出典データセットuspto-grants-2016_01
ORD IDord-6901464eb63f45489d7dd09189ad5d72
出典メモuspto-grants-2016_01