Dibenzo(b,d)furan-2-carboxaldehyde → 1-(Dibenzo[b,d]furan-2-ylmethyl)-7-(2,6-dimethoxyphenyl)azepan-2-one

HRID 594508ノート

反応式

HRID 594508 の反応式
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=O.[CH:21]1[C:29]2[C:28]3[CH:30]=[CH:31][CH:32]=[CH:33][C:27]=3[O:26][C:25]=2[CH:24]=[CH:23][C:22]=1[CH:34]=O>>[CH:21]1[C:29]2[C:28]3[CH:30]=[CH:31][CH:32]=[CH:33][C:27]=3[O:26][C:25]=2[CH:24]=[CH:23][C:22]=1[CH2:34][N:1]1[CH:2]([C:11]2[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=2[O:19][CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]1=[O:9]

参加物

3

反応物 2

HCID 220843Dibenzo(b,d)furan-2-carboxaldehydeHCID 69082587Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate

生成物 1

HCID 690810811-(Dibenzo[b,d]furan-2-ylmethyl)-7-(2,6-dimethoxyphenyl)azepan-2-one

実験手順

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate with commercially available dibenzo[b,d]furan-2-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions I): tR=1.53 min.; [M+H]+: 430.13 g/mol.

後処理

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

出典と根拠

ORDレコード
ord-98d301aeeff34de6beddf4b397abe0b0
出典データセット
uspto-grants-2016_01
特許番号
US09242970B2

反応ノート

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