2-Phenylpyridine-4-carbaldehyde → 5-(2,6-Dimethoxyphenyl)-1-((2-phenylpyridin-4-yl)methyl)pyrrolidin-2-one
反応式
[NH2:1][CH:2]([C:9]1[C:14]([O:15][CH3:16])=[CH:13][CH:12]=[CH:11][C:10]=1[O:17][CH3:18])[CH2:3][CH2:4][C:5]([O:7]C)=O.[C:19]1([C:25]2[CH:26]=[C:27]([CH:30]=[CH:31][N:32]=2)[CH:28]=O)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH3:18][O:17][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]([O:15][CH3:16])[C:9]=1[CH:2]1[N:1]([CH2:28][C:27]2[CH:30]=[CH:31][N:32]=[C:25]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:26]=2)[C:5](=[O:7])[CH2:4][CH2:3]1参加物
3
実験手順
Prepared according to the described general procedure 2 (GP2) by reaction of methyl 4-amino-4-(2,6-dimethoxyphenyl)butanoate with 2-phenylisonicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.61 min.; [M+H]+: 389.16 g/mol.
後処理
- customPrepared
- customSubsequent purification by preparative HPLC
- customafforded the target compound