戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 594614作成日：2026年10月26日

1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 5-(2,6-Dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

https://huagongshe.com/reaction/594614

反応式

関与物質

役割名称HCID仕込み量
反応物1-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 142785—
反応物5-(2,6-Dimethoxyphenyl)pyrrolidin-2-oneHCID 69080911—
生成物5-(2,6-Dimethoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-oneHCID 69085010—

反応手順

Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)pyrrolidin-2-one with commercially available 1-(bromomethyl)-4-(trifluoromethoxy)benzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.80 min.; [M+H]+: 396.00 g/mol.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09242970B2
出典データセットuspto-grants-2016_01
ORD IDord-377e750005df4e2db93d27fc07a67fc4
出典メモuspto-grants-2016_01