化工社化工社 化学情報印刷レポート · 研究参考用
4-Fluorobenzyl bromide → 5-(2,6-Dimethoxyphenyl)-1-(4-fluorobenzyl)pyrrolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorobenzyl bromide | HCID 68021 | — |
| 反応物 | 5-(2,6-Dimethoxyphenyl)pyrrolidin-2-one | HCID 69080911 | — |
| 生成物 | 5-(2,6-Dimethoxyphenyl)-1-(4-fluorobenzyl)pyrrolidin-2-one | HCID 69085756 | — |
反応手順
Prepared according to the described general procedure 4 (GP4) by reaction of 5-(2,6-dimethoxyphenyl)pyrrolidin-2-one with commercially available 1-(bromomethyl)-4-fluorobenzene. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions E): tR=0.71 min.; [M+H]+: 330.24 g/mol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09242970B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-12aed9d020874c699f39475e1f7b47d3 |
| 出典メモ | uspto-grants-2016_01 |