4-(Trifluoromethoxy)benzylamine → rac-(3R*,5S*)-5-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3-hydroxy-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

HRID 594678ノート

反応式

HRID 594678 の反応式
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH2:11])=[CH:6][CH:5]=1.[O:14]1[CH2:19][CH2:18][O:17][C:16]2[C:20]([CH:24]=O)=[CH:21][CH:22]=[CH:23][C:15]1=2>>[O:14]1[CH2:19][CH2:18][O:17][C:16]2[C:20]([CH:24]3[N:11]([CH2:10][C:7]4[CH:6]=[CH:5][C:4]([O:3][C:2]([F:12])([F:13])[F:1])=[CH:9][CH:8]=4)[C:15](=[O:14])[CH:16]([OH:17])[CH2:20]3)=[CH:21][CH:22]=[CH:23][C:15]1=2

参加物

3

反応物 2

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 27950332,3-Dihydro-1,4-benzodioxine-5-carbaldehyde

生成物 1

HCID 69085698rac-(3R*,5S*)-5-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-3-hydroxy-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one

実験手順

Prepared according to the described general procedures 10A2 (GP10A2), 10B (GP10B) and 10F (GP10F) using commercially available (4-(trifluoromethoxy)phenyl)methanamine and commercially available 2,3-dihydrobenzo[b][1,4]dioxine-5-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.79 min.; [M+H]+: 409.94 g/mol.

後処理

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

出典と根拠

ORDレコード
ord-e80721e70d9647bda7fe8d68bf7c834d
出典データセット
uspto-grants-2016_01
特許番号
US09242970B2

反応ノート

読み込み中…