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p-(Trifluoromethoxy)benzaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-(Trifluoromethoxy)benzaldehyde | HCID 69573 | — |
| 反応物 | Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate | HCID 69083532 | — |
| 生成物 | 5-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-(4-(trifluoromethoxy)benzyl)pyrrolidin-2-one | HCID 69084006 | — |
反応手順
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 4-(trifluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.97 min.; [M+H]+: 411.97 g/mol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09242970B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-1f74a17ff0ab4d00994bd4c706f8d5fa |
| 出典メモ | uspto-grants-2016_01 |