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HRID 594703作成日：2026年10月26日

3-Fluoro-4-(trifluoromethoxy)benzaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-1-(3-fluoro-4-(trifluoromethoxy)benzyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594703

反応式

関与物質

役割名称HCID仕込み量
反応物3-Fluoro-4-(trifluoromethoxy)benzaldehydeHCID 2783358—
反応物Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoateHCID 69083532—
生成物5-(2-Ethoxy-6-fluorophenyl)-1-(3-fluoro-4-(trifluoromethoxy)benzyl)-3-methylpyrrolidin-2-oneHCID 69083660—

反応手順

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 3-fluoro-4-(trifluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.98 min.; [M+H]+: 429.97 g/mol.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09242970B2
出典データセットuspto-grants-2016_01
ORD IDord-fd19b08752704f89a2aeb0827674ba71
出典メモuspto-grants-2016_01