戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 594706作成日：2026年10月27日

3-Chloro-4-(difluoromethoxy)benzaldehyde → 1-(3-Chloro-4-(difluoromethoxy)benzyl)-5-(2-ethoxy-6-fluorophenyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594706

反応式

関与物質

役割名称HCID仕込み量
反応物3-Chloro-4-(difluoromethoxy)benzaldehydeHCID 20274088—
反応物Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoateHCID 69083532—
生成物1-(3-Chloro-4-(difluoromethoxy)benzyl)-5-(2-ethoxy-6-fluorophenyl)-3-methylpyrrolidin-2-oneHCID 69082779—

反応手順

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 3-chloro-4-(difluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.93 min.; [M+H]+: 427.96 g/mol.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09242970B2
出典データセットuspto-grants-2016_01
ORD IDord-42a34b3d53744cb981fb2b31410d6e3f
出典メモuspto-grants-2016_01