3-Ethoxybenzaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-1-(3-ethoxybenzyl)-3-methylpyrrolidin-2-one

HRID 594707

反応式

HRID 594707 の反応式
[NH2:1][CH:2]([C:11]1[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=1[O:18][CH2:19][CH3:20])[CH2:3][CH:4]([CH3:10])[C:5]([O:7]CC)=O.[CH2:21]([O:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH:27]=O)[CH3:22]>>[CH2:19]([O:18][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]([F:17])[C:11]=1[CH:2]1[N:1]([CH2:27][C:26]2[CH:29]=[CH:30][CH:31]=[C:24]([O:23][CH2:21][CH3:22])[CH:25]=2)[C:5](=[O:7])[CH:4]([CH3:10])[CH2:3]1)[CH3:20]

参加物

3

反応物 2

HCID 899083-EthoxybenzaldehydeHCID 69083532Ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate

生成物 1

HCID 690845155-(2-Ethoxy-6-fluorophenyl)-1-(3-ethoxybenzyl)-3-methylpyrrolidin-2-one

実験手順

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 3-ethoxybenzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.92 min.; [M+H]+: 372.03 g/mol.

後処理

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

出典と根拠

ORDレコード
ord-8fa82841ee294f60b7591a6be06b96a0
出典データセット
uspto-grants-2016_01
特許番号
US09242970B2

関連ノート

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