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HRID 594719作成日：2026年10月27日

1-Methylindole-2-carboxaldehyde → 5-(2,6-dimethoxyphenyl)-3-methyl-1-((1-methyl-1H-indol-2-yl)methyl)pyrrolidin-2-one

https://huagongshe.com/reaction/594719

反応式

関与物質

役割名称HCID仕込み量
反応物1-Methylindole-2-carboxaldehydeHCID 267164—
反応物Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoateHCID 69085588—
生成物5-(2,6-dimethoxyphenyl)-3-methyl-1-((1-methyl-1H-indol-2-yl)methyl)pyrrolidin-2-oneHCID 69082757—

反応手順

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with commercially available 1-methyl-1H-indole-2-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.90 min.; [M+H]+: 379.05 g/mol.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09242970B2
出典データセットuspto-grants-2016_01
ORD IDord-7b819844a024498aaac5e08a512f8a9f
出典メモuspto-grants-2016_01