1-methyl-1H-indole-5-carbaldehyde → HCID 69084514、化合物

HRID 594722

反応式

HRID 594722 の反応式
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH:4]([CH3:10])[C:5]([O:7]CC)=O.[CH3:21][N:22]1[C:30]2[C:25](=[CH:26][C:27]([CH:31]=O)=[CH:28][CH:29]=2)[CH:24]=[CH:23]1>>[CH3:18][O:17][C:16]1[CH:15]=[CH:14][CH:13]=[C:12]([O:19][CH3:20])[C:11]=1[CH:2]1[N:1]([CH2:31][C:27]2[CH:26]=[C:25]3[C:30](=[CH:29][CH:28]=2)[N:22]([CH3:21])[CH:23]=[CH:24]3)[C:5](=[O:7])[CH:4]([CH3:10])[CH2:3]1

参加物

3

反応物 2

HCID 75375341-methyl-1H-indole-5-carbaldehydeHCID 69085588Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate

生成物 1

HCID 69084514HCID 69084514、化合物

実験手順

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with commercially available 1-methyl-1H-indole-5-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.84 min.; [M+H]+: 378.93 g/mol.

後処理

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

出典と根拠

ORDレコード
ord-afd129c27ea94903b2d9002c22c5399c
出典データセット
uspto-grants-2016_01
特許番号
US09242970B2

関連ノート

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