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HRID 594730作成日：2026年10月26日

p-(Difluoromethoxy)benzaldehyde → 1-(4-(Difluoromethoxy)benzyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-one

https://huagongshe.com/reaction/594730

反応式

関与物質

役割名称HCID仕込み量
反応物p-(Difluoromethoxy)benzaldehydeHCID 2736986—
反応物Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoateHCID 69085588—
生成物1-(4-(Difluoromethoxy)benzyl)-5-(2,6-dimethoxyphenyl)-3-methylpyrrolidin-2-oneHCID 69083449—

反応手順

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with commercially available 4-(difluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.86 min.; [M+H]+: 391.78 g/mol.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09242970B2
出典データセットuspto-grants-2016_01
ORD IDord-c0a1dc422846477c96b49f7f5e41cbd3
出典メモuspto-grants-2016_01