化工社化工社 化学情報印刷レポート · 研究参考用
3-(2,2,2-Trifluoroethoxy)benzaldehyde → 5-(2,6-Dimethoxyphenyl)-3-methyl-1-(3-(2,2,2-trifluoroethoxy)benzyl)pyrrolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(2,2,2-Trifluoroethoxy)benzaldehyde | HCID 4770947 | — |
| 反応物 | Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate | HCID 69085588 | — |
| 生成物 | 5-(2,6-Dimethoxyphenyl)-3-methyl-1-(3-(2,2,2-trifluoroethoxy)benzyl)pyrrolidin-2-one | HCID 69082495 | — |
反応手順
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with 3-(2,2,2-trifluoroethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.90 min.; [M+H]+: 424.43 g/mol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09242970B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-8a91e520e0a3481f97315bf4378cf23e |
| 出典メモ | uspto-grants-2016_01 |