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4-(2-Fluoroethoxy)benzaldehyde → 5-(2,6-Dimethoxyphenyl)-1-(4-(2-fluoroethoxy)benzyl)-3-methylpyrrolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(2-Fluoroethoxy)benzaldehyde | HCID 15058649 | — |
| 反応物 | Ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate | HCID 69085588 | — |
| 生成物 | 5-(2,6-Dimethoxyphenyl)-1-(4-(2-fluoroethoxy)benzyl)-3-methylpyrrolidin-2-one | HCID 86695665 | — |
反応手順
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with 4-(2-fluoroethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.81 min.; [M+H]+: 388.05 g/mol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09242970B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-675eb294a733433cb140958709bea523 |
| 出典メモ | uspto-grants-2016_01 |