3-(Pyrimidin-2-yl)benzaldehyde → 6-(2-Methoxynaphthalen-1-yl)-1-(3-(pyrimidin-2-yl)benzyl)piperidin-2-one

HRID 594753ノート

反応式

HRID 594753 の反応式
[NH2:1][CH:2]([C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:12][C:11]=1[O:20][CH3:21])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[N:22]1[CH:27]=[CH:26][CH:25]=[N:24][C:23]=1[C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=1)[CH:31]=O>>[CH3:21][O:20][C:11]1[CH:12]=[CH:13][C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:10]=1[CH:2]1[N:1]([CH2:31][C:30]2[CH:33]=[CH:34][CH:35]=[C:28]([C:23]3[N:22]=[CH:27][CH:26]=[CH:25][N:24]=3)[CH:29]=2)[C:6](=[O:8])[CH2:5][CH2:4][CH2:3]1

参加物

3

反応物 2

HCID 226308183-(Pyrimidin-2-yl)benzaldehydeHCID 69082274Methyl 5-amino-5-(2-methoxynaphthalen-1-yl)pentanoate

生成物 1

HCID 690852246-(2-Methoxynaphthalen-1-yl)-1-(3-(pyrimidin-2-yl)benzyl)piperidin-2-one

実験手順

Prepared according to general procedure 1 (GP1) using methyl 5-amino-5-(2-methoxynaphthalen-1-yl)pentanoate and commercially available 3-(pyrimidin-2-yl)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.84 min.; [M+H]+: 424.10 g/mol.

後処理

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

出典と根拠

ORDレコード
ord-50c5eaa085004530b34518d2b567d3fa
出典データセット
uspto-grants-2016_01
特許番号
US09242970B2

反応ノート

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