Imidazole → tert-Butyl (3S)-3-(iodomethyl)pyrrolidine-1-carboxylate

Triphenylphosphine (182.2 g, 695 mmol) and imidazole (47.4 g, 696 mmol) were dissolved in dichloromethane (1.6 L), and iodine (70.4 g, 555 mmol) was then added to the above obtained solution under ice-cold condition. The obtained mixture was stirred for 10 minutes. After that, a dichloromethane solution (200 mL) of the (S)-tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate (55.8 g, 278 mmol) synthesized by a method described in the known method (Bioorg. Med. Chem. Lett., 19, 2829-2834 (2009)) was further added to the reaction solution, and the obtained mixture was then stirred at room temperature for 15 hours. Thereafter, the reaction solution was washed with an aqueous solution of sodium sulfite, was then dried over anhydrous sodium sulfate, and was then concentrated in vacuo. The obtained residue was purified by silica gel chromatography (hexane/ethyl acetate=2%→25%) to obtain (S)-tert-butyl 3-(iodomethyl)pyrrolidine-1-carboxylate (73.2 g, 85%) in the form of a colorless oily product.

1. additionwas further added to the reaction solution
2. stirringthe obtained mixture was then stirred at room temperature for 15 hours
3. washThereafter, the reaction solution was washed with an aqueous solution of sodium sulfite
4. dry with materialwas then dried over anhydrous sodium sulfate
5. concentrationwas then concentrated in vacuo
6. customThe obtained residue was purified by silica gel chromatography (hexane/ethyl acetate=2%→25%)

ORDレコード

ord-b6954e3cf9c340419b0a950635589c5f

出典データセット

uspto-grants-2016_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09242978B2