Ammonia → 6'-Bromo-2',2'-dimethyldispiro[1,3-oxazole-4,4'-chromene-3',3''-oxetan]-2-amine

Under an argon atmosphere, to a mixture of 6-bromo-2,2-dimethyl-4-methylene-4H-spiro[chromene-3,3′-oxetane] (504 mg, 1.71 mmol), silver cyanate (384 mg, 2.56 mmol) and EtOAc-MeCN (1:1, 5.0 mL) was added iodine (649 mg, 2.56 mmol) over 5 minutes in an ice-water bath. After stirring for 30 minutes at the same temperature, the mixture was filtered through celite pad. The filtrate was washed with saturated aqueous Na2S2O3 and brine, dried over MgSO4 and filtered. After concentration of the filtrate at reduced pressure, the residue was dissolved in THF (5.0 mL). The solution was added to 2 M EtOH solution of ammonia (10.7 mL, 21.4 mmol) in an ice-water bath. The mixture was stirred for 1 hour in the bath and 3 hours at 70° C. After cooling down to ambient temperature, NH-silica gel was added to the reaction mixture, and the mixture was concentrated at reduced pressure. The residue was purified with column chromatography on silica gel (CHCl3-EtOH, a linear gradient of EtOH from 0 to 20%) to afford 6′-bromo-2′,2′-dimethyldispiro[1,3-oxazole-4,4′-chromene-3′,3″-oxetan]-2-amine (483 mg).

1. filtrationthe mixture was filtered through celite pad
2. washThe filtrate was washed with saturated aqueous Na2S2O3 and brine
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. dissolutionAfter concentration of the filtrate at reduced pressure, the residue was dissolved in THF (5.0 mL)
6. stirringThe mixture was stirred for 1 hour in the bath and 3 hours at 70° C
7. additionNH-silica gel was added to the reaction mixture
8. concentrationthe mixture was concentrated at reduced pressure
9. customThe residue was purified with column chromatography on silica gel (CHCl3-EtOH

ORDレコード

ord-b8ec78aad9334d9b86240aadf912baf2

出典データセット

uspto-grants-2016_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09242973B2