Phosphorus tribromide → HCID 67112138、化合物
反応式
O[CH2:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH2:7][C:8]([NH2:10])=[O:9].P(Br)(Br)[Br:15]>ClCCl>[Br:15][CH2:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH2:7][C:8]([NH2:10])=[O:9]参加物
4
反応条件
- 温度
- 0 °C
実験手順
2-(3-(hydroxymethyl)phenoxy)acetamide (320 mg, 1.76 mmol) was suspended in dichloromethane (12 mL) and the suspension cooled to 0° C. (ice bath). Phosphorus tribromide (1.5 eq) was added slowly and the reaction allowed to warm to rt. After stirring for 18 h the reaction was quenched by addition of NaHCO3 (sat., aq). The product was extracted with dichloromethane, dried (Na2SO4), filtered and concentrated in vacuo to afford 2-(3-(bromomethyl)phenoxy)acetamide as a white solid.
後処理
- temperatureto warm to rt
- customwas quenched by addition of NaHCO3 (sat., aq)
- extractionThe product was extracted with dichloromethane
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-3457c9591d86463eab43a351505e0c1c
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242987B2
反応ノート
読み込み中…