Acetic Acid → HCID 89494514、化合物
反応式
C(S[C:4]1[NH:5][C:6](=[O:14])[C:7]2[CH2:12][S:11][CH:10]([CH3:13])[C:8]=2[N:9]=1)C.Cl.CC(O)=[O:18]>O>[CH3:13][CH:10]1[C:8]2[NH:9][C:4](=[O:18])[NH:5][C:6](=[O:14])[C:7]=2[CH2:12][S:11]1参加物
5
実験手順
To a suspension of 2-(ethylthio)-7-methylthieno[3,4-d]pyrimidin-4(3H,5H,7H)-one (3.96 g, 17.3 mmol) in water (20 mL) was added 2.0 mL of conc. HCl and 4.0 mL of AcOH. The mixture was heated to reflux overnight then cooled and the precipitated solid collected by filtration, washed with water and methanol, evaporated and dried to obtain 7-methylthieno[3,4-d]pyrimidine-2,4(1H,3H,5H,7H)-dione as a white solid (2.52 g, 80%). Without further purification, the crude product was used directly in the next step.
後処理
- temperatureThe mixture was heated
- temperatureto reflux overnight
- temperaturethen cooled
- filtrationthe precipitated solid collected by filtration
- washwashed with water and methanol
- customevaporated
- customdried
出典と根拠
- ORDレコード
- ord-0a4dc8363f3044749f2618383848e550
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242993B2
反応ノート
読み込み中…