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1,2-Dichloroethane → (5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dichloroethane | HCID 11 | — |
| 反応物 | 6-(((Tert-butoxy)carbonyl)(ethyl)amino)pyridine-3-carboxylic acid | HCID 66769552 | — |
| 生成物 | (5-Chlorocarbonyl-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester | HCID 86664610 | — |
反応手順
6-(tert-Butoxycarbonyl-ethyl-amino)-nicotinic acid (6.40 g, 24.0 mmol) is taken up in 150 mL DCE, 1-chloro-N,N-2-trimethylpropenyl-amine (6.42 mL, 48.1 mmol) is added and the reaction mixture is stirred overnight at RT. The reaction mixture is concentrated under reduced pressure and the crude product is used in the next step without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09243000B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-068c5445f3374fb9b532cbba1e893995 |
| 出典メモ | uspto-grants-2016_01 |