Chloroacetaldehyde → HCID 90427811、化合物
反応式
[NH2:1][C:2]1[N:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[C:3]=1[C:4]#[N:5].Cl[CH2:13][CH:14]=O>O>[CH3:10][C:8]1[N:9]2[CH:13]=[CH:14][N:1]=[C:2]2[C:3]([C:4]#[N:5])=[C:6]([CH3:11])[CH:7]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a stirred solution of compound 2-amino-4,6-dimethylnicotinonitrile (1 equiv.) in water was added chloroacetaldehyde (55% aq. solution) (1.2 equiv.) and reaction was heated at 80° C. for 16 h. On completion, it was quenched by 1N NaOH till pH 8. Solid precipitated was filtered and vacuum dried to afford the title compound (75% yield).
後処理
- customOn completion, it was quenched by 1N NaOH till pH 8
- customSolid precipitated
- filtrationwas filtered
- customvacuum dried
出典と根拠
- ORDレコード
- ord-406b2916140c43b5b7e1954cbde28cbd
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09243001B2
反応ノート
読み込み中…