化工社化工社 化学情報印刷レポート · 研究参考用
Benzoic Acid → N'-benzoyl-6-chloro-4-(isopropylamino)nicotinohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoic Acid | HCID 243 | — |
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 6-Chloro-4-(isopropylamino)nicotinohydrazide | HCID 89689668 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N'-benzoyl-6-chloro-4-(isopropylamino)nicotinohydrazide | HCID 89689702 | — |
反応手順
6-chloro-4-(isopropylamino)nicotinohydrazide (10) (500 mg, 2.1 mmol) and benzoic acid (2.1 mmol, 1 equiv.) were dissolved in DMF (10 mL). EDC.HCl (1.5 equiv.), DIPEA (3 equiv.) and HOBT (1.5 equiv.) were added to the reaction mixture and stirred at room temperature for 5 h. The reaction mass was concentrated under reduced pressure to remove excess of solvent present. Diluted the residue with EtOAc and washed water followed by brine solution. The organic layer was collected, dried over Na2SO4, filtered and concentrated to get N′-benzoyl-6-chloro-4-(isopropylamino)nicotinohydrazide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09242975B2 |
| 出典データセット | uspto-grants-2016_01 |
| ORD ID | ord-4cc06ae56bfc4f3fb1b9aef0139a49f5 |
| 出典メモ | uspto-grants-2016_01 |