ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Potassium Carbonate → 5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(1H-imidazol-1-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

HRID 595576
ノート
印刷プレビュー

反応式

HRID 595576 の反応式
[N:1]1([C:6]2[O:7][C:8]3[CH:18]=[C:17]([N:19]([CH3:24])[S:20]([CH3:23])(=[O:22])=[O:21])[C:16](B4OC(C)(C)C(C)(C)O4)=[CH:15][C:9]=3[C:10]=2[C:11]([NH:13][CH3:14])=[O:12])[CH:5]=[CH:4][N:3]=[CH:2]1.Cl[C:35]1[CH:36]=[CH:37][C:38]2[O:51][CH2:50][N:41]3[C:42]4[CH:43]=[CH:44][CH:45]=[C:46]([F:49])[C:47]=4[CH:48]=[C:40]3[C:39]=2[N:52]=1.C([O-])([O-])=O.[K+].[K+].CC(C1C=C(C(C)C)C(C2C=CC=CC=2P(C2CCCCC2)C2CCCCC2)=C(C(C)C)C=1)C>O1CCOCC1.O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[F:49][C:46]1[C:47]2[CH:48]=[C:40]3[C:39]4[N:52]=[C:35]([C:16]5[C:17]([N:19]([CH3:24])[S:20]([CH3:23])(=[O:22])=[O:21])=[CH:18][C:8]6[O:7][C:6]([N:1]7[CH:5]=[CH:4][N:3]=[CH:2]7)=[C:10]([C:11]([NH:13][CH3:14])=[O:12])[C:9]=6[CH:15]=5)[CH:36]=[CH:37][C:38]=4[O:51][CH2:50][N:41]3[C:42]=2[CH:43]=[CH:44][CH:45]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

8

反応物 4

HCID 11430Potassium CarbonateHCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 867283052-chloro-11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indoleHCID 903336142-(1H-imidazol-1-yl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

生成物 1

HCID 77845758
5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(1H-imidazol-1-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
収率 40%

試薬・触媒・溶媒 3

HCID 9811564Bis(dibenzylideneacetone)palladium触媒HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

反応条件

温度
110 °C

実験手順

To a solution of 2-(1H-imidazol-1-yl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide (60 mg, 0.13 mmol), 2-chloro-11-fluoro-6H-pyrido[2′,3′:5,6][1,3]oxazino[3,4-a]indole (42 mg, 0.15 mmol) and K2CO3 (26 mg, 0.19 mmol) in 1,4-dioxane (1 mL) and water (0.01 mL) were added X-Phos (10 mg) and Pd2(dba)3 (10 mg) under nitrogen. The mixture was heated at 110° C. for 3 hours and filtered through the celite pad. The filtrate was extracted with EtOAc and the combined organic phase was washed with brine, dried over Na2SO4 and concentrated in vacuo. The crude product was purified by prep-HPLC to give 5-(11-fluoro-6H-pyrido[2′,3′:5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(1H-imidazol-1-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (30 mg, yield: 40%). 1H-NMR (400 MHz, CDCl3) δ 8.36 (s, 1H), 8.03 (s, 1H), 7.73 (s, 1H), 7.68 (s, 1H), 7.52 (s, 2H), 7.20˜7.25 (m, 3H), 7.12 (d, J=8.4 Hz, 1H), 6.84˜6.88 (m, 1H), 6.02 (s, 2H), 5.93 (d, J=4.8 Hz, 1H), 3.35 (s, 3H), 3.02 (d, J=4.8 Hz, 3H), 2.78 (s, 3H). MS (M+H)+: 587.

後処理

  1. filtrationfiltered through the celite pad
  2. extractionThe filtrate was extracted with EtOAc
  3. washthe combined organic phase was washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo
  6. customThe crude product was purified by prep-HPLC

出典と根拠

ORDレコード
ord-69ac8263a5044e4a93128946c6ef7a86
出典データセット
uspto-grants-2016_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09242998B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート