Hydrochloric Acid → (S)-2-amino-2-(3-fluoro-5-iodophenyl)ethanol hydrochloride
反応式
[F:1][C:2]1[CH:3]=[C:4]([C@H:9]([NH:12]C(=O)OC(C)(C)C)[CH2:10][OH:11])[CH:5]=[C:6]([I:8])[CH:7]=1.[ClH:20].O1CCOCC1>C(Cl)Cl>[ClH:20].[NH2:12][C@@H:9]([C:4]1[CH:5]=[C:6]([I:8])[CH:7]=[C:2]([F:1])[CH:3]=1)[CH2:10][OH:11]参加物
5
実験手順
(S)-tert-butyl (1-(3-fluoro-5-iodophenyl)-2-hydroxyethyl)carbamate (2.507 g, 6.58 mmol) was dissolved in DCM (60 mL) and treated with 4 N HCl in dioxane (4.93 mL, 19.73 mmol). The mixture was stirred overnight at room temperature. After the majority of the solvent was evaporated carefully in vacuo, the slurry was triturated with Et2O to afford 1.525 g of a fine white HCl salt of (S)-2-amino-2-(3-fluoro-5-iodophenyl)ethanol (72%), which was isolated by suction filtration. LCMS (m/z): 282.4 (MH+), 0.46 min.
後処理
- customAfter the majority of the solvent was evaporated carefully in vacuo
- customthe slurry was triturated with Et2O
出典と根拠
- ORDレコード
- ord-364c6127db4b40d18a17a111bef4af86
- 出典データセット
- uspto-grants-2016_01
- 特許番号
- US09242996B2
反応ノート
読み込み中…