Potassium hydroxide ethanol → 5-Bromo-2-(7-bromo-9,9'-Dioctyl-9H-fluoren-2-yl)benzoic acid

HRID 596137ノート

反応式

HRID 596137 の反応式
C[O:2][C:3](=[O:41])[C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[CH:6][C:5]=1[C:11]1[CH:23]=[CH:22][C:21]2[C:20]3[C:15](=[CH:16][C:17]([Br:24])=[CH:18][CH:19]=3)[C:14]([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[C:13]=2[CH:12]=1.[OH-].[K+].C(O)C>C(O)C>[Br:10][C:8]1[CH:7]=[CH:6][C:5]([C:11]2[CH:23]=[CH:22][C:21]3[C:20]4[C:15](=[CH:16][C:17]([Br:24])=[CH:18][CH:19]=4)[C:14]([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[C:13]=3[CH:12]=2)=[C:4]([CH:9]=1)[C:3]([OH:41])=[O:2]

参加物

4

反応物 2

HCID 21946426Potassium hydroxide ethanolHCID 867235505-Bromo-2-(7-bromo-9,9'-Dioctyl-9H-fluoren-2-yl)benzoic acid methyl ester

生成物 1

HCID 586075385-Bromo-2-(7-bromo-9,9'-Dioctyl-9H-fluoren-2-yl)benzoic acid収率 102.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

35 g (51.2 mmol) 16 is suspended in 300 ml ethanol and treated with 50 ml 50% KOH/ethanol solution and heated to reflux for 3 h. After cooling to room temperature with reaction mixture is diluted with 200 ml ethanol, with precipitation is collected by filtration, the residue is washed with ethanol and dried in vacuum. 35 g (yield: 98%) of a white solid can be obtained.

後処理

  1. temperatureheated
  2. temperatureto reflux for 3 h
  3. filtrationis collected by filtration
  4. washthe residue is washed with ethanol
  5. customdried in vacuum

出典と根拠

ORDレコード
ord-563a2223e3b2475a85831acdb2feaa2f
出典データセット
uspto-grants-2016_01
特許番号
US09246103B2

反応ノート

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