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4-Aminophenol → 4-(acetylamino)-N-(4-hydroxyphenyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminophenol | HCID 403 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | p-Acetamidobenzoic acid | HCID 19266 | — |
| 反応物 | Isobutyl chloroformate | HCID 62365 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 4-(acetylamino)-N-(4-hydroxyphenyl)benzamide | HCID 869595 | — |
反応手順
A solution of p-acetamidobenzoic acid (12.5 g.) in 250 ml. of tetrahydrofuran is treated with triethylamine (11.1 ml.). The mixture is then treated with isobutylchloroformate (10.4 ml.) and, after 5 min. at about 25° C., with p-aminophenol (13.3 g.) in 80 ml. of dry pyridine. After 40 min. the crude product is obtained by addition of 2 liters of water. The product is recrystallized from 500 ml. of hot methanol by dilution with 300 ml. of water as white crystals, 5.9 g., m.p. 275.0°-277.0° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04010172 |
| 出典データセット | uspto-grants-1977_03 |
| ORD ID | ord-293fe4c4febd491faf717d9bd6c6b30c |
| 出典メモ | uspto-grants-1977_03 |