1-(3,4-Dimethylphenyl)hydrazine hydrochloride → HCID 178493807、化合物

HRID 59617

反応式

HRID 59617 の反応式
C([O:3][C:4]([C:6](=[N:10][NH:11][C:12]1[C:13]([O:27][CH3:28])=[C:14]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([OH:26])=[O:25])[CH:19]=2)[CH:15]=[CH:16][CH:17]=1)[C:7](=O)[CH3:8])=O)C.Cl.[CH3:30][C:31]1[CH:32]=[C:33]([NH:38][NH2:39])[CH:34]=[CH:35][C:36]=1[CH3:37].C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH3:30][C:31]1[CH:32]=[C:33]([N:38]2[C:4](=[O:3])[C:6](=[N:10][NH:11][C:12]3[C:13]([O:27][CH3:28])=[C:14]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([OH:26])=[O:25])[CH:19]=4)[CH:15]=[CH:16][CH:17]=3)[C:7]([CH3:8])=[N:39]2)[CH:34]=[CH:35][C:36]=1[CH3:37]

参加物

5

反応物 3

HCID 1737401-(3,4-Dimethylphenyl)hydrazine hydrochlorideHCID 517045Sodium AcetateHCID 178472848HCID 178472848、化合物

生成物 1

HCID 178493807HCID 178493807、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 3′-{-2-[1-(ethoxycarbonyl)-2-oxopropylidene]hydrazino}-2′-methoxybiphenyl-3-carboxylic acid (3.5 g) prepared as in Example 7, and 3,4-dimethylphenylhydrazine hydrochloride (1.72 g) and sodium acetate(0.9 g) in glacial acetic acid (120 mL) was stirred and heated to about reflux temperature for about 4 hours. The mixture was cooled to about room temperature and stirred for about 1 hour. It was filtered, washed with water (25 mL) and dried in an oven at about 55° C. to about 60° C. for about 12 hours to an orange solid.

後処理

  1. temperatureheated
  2. temperatureto about reflux temperature for about 4 hours
  3. temperatureThe mixture was cooled to about room temperature
  4. stirringstirred for about 1 hour
  5. filtrationIt was filtered
  6. washwashed with water (25 mL)
  7. customdried in an oven at about 55° C. to about 60° C. for about 12 hours to an orange solid

出典と根拠

ORDレコード
ord-0c8c0b79afbf47369d84effd78195d22
出典データセット
uspto-grants-2016_09
特許番号
US09440927B2

関連ノート

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