Benzene → 4-Fluoroanilinium 2,3-dichloromaleate

HRID 596185

反応式

HRID 596185 の反応式
[Cl:1]/[C:2](=[C:6](\[Cl:10])/[C:7]([OH:9])=[O:8])/[C:3]([OH:5])=[O:4].[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1.C1C=CC=CC=1>>[Cl:1]/[C:2](=[C:6](\[Cl:10])/[C:7]([O-:9])=[O:8])/[C:3]([O-:5])=[O:4].[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH3+:16])=[CH:14][CH:13]=1.[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH3+:16])=[CH:14][CH:13]=1

参加物

4

反応物 3

HCID 241Benzene2 回HCID 97314-FluoroanilineHCID 6437972,3-Dichloromaleic acid

生成物 1

HCID 867345124-Fluoroanilinium 2,3-dichloromaleate収率 98.7%

実験手順

9.25g (0.05 mol) of 2,3-dichloromaleic acid was dissolved in 50 ml of benzene. To the resulting solution 20 ml of benzene containing 5.55g (0.05 mol) of 4-fluoroaniline was added dropwise over a period of 20 min. at temperatures of 15°-25° C under agitation. After completing the addition, the mixture was agitated at that temperature for 30 min. during which time crystals formed, which were separated by filtration and washed with benzene to obtain 14.7g of 4-fluoroanilinium 2,3-dichloromaleate in the form of white crystal at a yield of 98.7%. The crystal had a melting point (decomposition point) of 207° C and is expressed by the following formula: ##STR2## The results of elementary analysis were as follows:

後処理

  1. additionthe addition
  2. customformed
  3. customwhich were separated by filtration
  4. washwashed with benzene

出典と根拠

ORDレコード
ord-5f974ed8abf444429e3d6d7a89afed69
出典データセット
uspto-grants-1977_03
特許番号
US04010182

関連ノート

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