4-Fluoroaniline → Fluoroimide
反応式
[Cl:1]/[C:2](=[C:7](\[Cl:12])/[C:8](OC)=[O:9])/[C:3](OC)=[O:4].[F:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1>O>[F:13][C:14]1[CH:20]=[CH:19][C:17]([N:18]2[C:3](=[O:4])[C:2]([Cl:1])=[C:7]([Cl:12])[C:8]2=[O:9])=[CH:16][CH:15]=1参加物
4
実験手順
15g (0.07 mol) of dimethyl 2,3-dichloromaleate was added to 100 ml of water. To the resulting solution 6.7g (0.06 mol) of 4-fluoroaniline was added dropwise over a period of 5 min. at reflux temperatures under agitation. The mixture was then allowed to react for 2 hours at reflux temperatures. Upon cooling the reaction mixture, precipitated crystal was separated by filtration to obtain 15.2g of N-(4-fluorophenyl)-2,3-dichloromaleimide melting at 240°-242° C (not corrected) at a yield of 97.3%. An analysis by gas chromatography showed the product had a purity of 94.1%.