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Aminoethyl sulfate → 2-(2-Hydroxy-4-phenylbutyl)aminoethyl hydrogen sulphate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aminoethyl sulfate | HCID 70223 | — |
| 反応物 | 2-(2-Phenylethyl)oxirane | HCID 135955 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 2-(2-Hydroxy-4-phenylbutyl)aminoethyl hydrogen sulphate | HCID 20354781 | — |
反応手順
A mixture of 1,2-epoxy-4-phenylbutane (1.48 g.) and 2-aminoethyl hydrogen sulphate (7.05 g.) in methanol (7.5 ml.) and sodium hydroxide solution (18N, 2.8 ml.) is stirred at ambient temperature for 2 hours. The 2-(2-hydroxy-4-phenylbutyl)aminoethyl hydrogen sulphate formed as intermediate is not isolated but is cyclised in situ as follows:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04010266 |
| 出典データセット | uspto-grants-1977_03 |
| ORD ID | ord-241d6d8f0f204c859c915f205a38dc50 |
| 出典メモ | uspto-grants-1977_03 |