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Chloroacetyl chloride → 1H-1,4-Benzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 7-chloro-2-hydrazino-5-(2,6-difluorophenyl)-3H-1,4-benzodiazepine | HCID 20291823 | — |
| 生成物 | 1H-1,4-Benzodiazepine | HCID 148431 | — |
反応手順
In the manner given in Preparation 10, 7-chloro-5(2,6-difluorophenyl)-3H-1,4-benzodiazepin-2-yl hydrazine is reacted with chloroacetyl chloride and after 1.5 hours with sodium acetate, then the mixture is refluxed to give 8-chloro-1-(chloromethyl)-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4-benzodiazepine. Preparation 14 8-Nitro-1-(bromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04010177 |
| 出典データセット | uspto-grants-1977_03 |
| ORD ID | ord-e1ceb363288a48ba9780f4b7d7d00abc |
| 出典メモ | uspto-grants-1977_03 |