HCID 12674605、化合物 → 2-Imidazolidinone, 1-(3-chlorophenyl)-3-(2-(3,3-dipropyl-1-azetidinyl)-1-methylethyl)-4-methyl-

HRID 596464ノート

反応式

HRID 596464 の反応式
Cl[CH2:2][CH:3]([N:5]1[CH:9]([CH3:10])[CH2:8][N:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[C:6]1=[O:18])[CH3:4].[CH2:19]([C:22]1([CH2:26][CH2:27][CH3:28])[CH2:25][NH:24][CH2:23]1)[CH2:20][CH3:21]>C1C=CC=CC=1>[Cl:17][C:13]1[CH:12]=[C:11]([N:7]2[CH2:8][CH:9]([CH3:10])[N:5]([CH:3]([CH3:4])[CH2:2][N:24]3[CH2:25][C:22]([CH2:26][CH2:27][CH3:28])([CH2:19][CH2:20][CH3:21])[CH2:23]3)[C:6]2=[O:18])[CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 12674605HCID 12674605、化合物HCID 12674606HCID 12674606、化合物

生成物 1

HCID 30402912-Imidazolidinone, 1-(3-chlorophenyl)-3-(2-(3,3-dipropyl-1-azetidinyl)-1-methylethyl)-4-methyl-

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of 7 g. of 3-(2-chloro-1-methylethyl)-1-(m-chlorophenyl)-4-methyl-2-imidazolidinone and 10 g. of 3,3-dipropylazetidine in 100 ml. of anhydrous benzene is heated in a bomb at 150°-160° C. for 8 hours. The solvent is evaporated under vacuum and the residue is taken up with water, alkalinized with aqueous sodium carbonate and extracted with diethyl ether. The residue obtained by evaporation of the organic layer is purified by column chromatography through silica gel, using as the eluent chloroform containing 8% of methanol. Yield 8.6 g., b.p. 220° C./0.5 mm Hg.

後処理

  1. additionA mixture of 7 g
  2. customThe solvent is evaporated under vacuum
  3. extractionextracted with diethyl ether
  4. customThe residue obtained by evaporation of the organic layer
  5. customis purified by column chromatography through silica gel

出典と根拠

ORDレコード
ord-052635ad402b40818815f6a1da4f7caa
出典データセット
uspto-grants-1977_03
特許番号
US04011238

反応ノート

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