2-(1H-benzimidazol-2-yl)isoindole-1,3-dione → N-(benzimidazol-2-yl)-2-(n-butoxycarbonyl)-benzamide

HRID 596574

反応式

HRID 596574 の反応式
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20]>C(O)CCC>[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[NH:10][C:14](=[O:15])[C:13]1[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=1[C:11]([O:15][CH2:14][CH2:13][CH2:12][CH3:11])=[O:20]

参加物

3

反応物 1

HCID 27557042-(1H-benzimidazol-2-yl)isoindole-1,3-dione

生成物 1

HCID 21449938N-(benzimidazol-2-yl)-2-(n-butoxycarbonyl)-benzamide

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

N-(Benzimidazol-2-yl)phthalimide (4 g.) in 200 ml. of n-butyl alcohol is heated at 115° C. for 35 minutes. On cooling, colorless needles form. These are removed by suction filtration, washed with butyl alcohol and finally with diethyl ether. After drying for three hours at 125° C. under vacuum, a yield of 2.5 g. of N-(benzimidazol-2-yl)-2-(n-butoxycarbonyl)-benzamide, m.p. 187° C., is obtained. Additional heating to higher temperatures causes a reclosure to the phthalimide and remelting which corresponds to the phthalimide, m.p. 267°-268° C.

後処理

  1. temperatureOn cooling
  2. customcolorless needles form
  3. customThese are removed by suction filtration
  4. washwashed with butyl alcohol and finally with diethyl ether
  5. customAfter drying for three hours at 125° C. under vacuum

出典と根拠

ORDレコード
ord-95940ae3f397417aa28f55ef2a7ccea5
出典データセット
uspto-grants-1977_03
特許番号
US04011236

関連ノート

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