関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Styrene Oxide | HCID 7276 | — |
| 反応物 | (+-)-3,4-Dimethoxyamphetamine | HCID 8423 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | N-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2-hydroxy-2-phenylethylamine | HCID 11347606 | — |
反応手順
A mixture of 20 g. (0.102 mol) of 1-(3,4-dimethoxyphenyl)-2-aminopropane and 12.01 ml. (0.102 mol) of styrene oxide is heated and stirred at 100° C. under argon for 18 hours. The cooled reaction mixture is dissolved in a minimum amount of benzene and petroleum ether is then added to precipitate a solid which turned to a liquid upon standing. Fractional vacuum distillation yields N-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2-hydroxy-2-phenylethylamine, b.p. 205°-225° C./0.2 mm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04011319 |
|---|
| 出典データセット | uspto-grants-1977_03 |
|---|
| ORD ID | ord-b713955d61084a38a3d57eaa2081338a |
|---|
| 出典メモ | uspto-grants-1977_03 |
|---|
