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Water → 5-(3,7,11,15-Tetramethylhexadecyloxy)-2-furoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Dihydrophytol | HCID 102459 | — |
| 反応物 | 5-Chlorofuran-2-carboxylic acid | HCID 234853 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-(3,7,11,15-Tetramethylhexadecyloxy)-2-furoic acid | HCID 21450431 | — |
反応手順
A mixture of 59.8 g (0.2 mole) of 3,7,11,15-tetramethyl-1-hexadecanol and 19.2 g (0.4 mole) of sodium hydride (50% in oil) in 1 liter of toluene is refluxed with stirring for 2 hours then cooled to room temperature. To the mixture 29.3 g (0.2 mole) of 5-chloro-2-furoic acid is added and the mixture is refluxed with stirring for 24 hours. Upon cooling to room temperature the mixture is acidified with glacialacetic acid and water is added. The toluene layer is evaporated and allowed to crystallize to give 5-(3,7,11,15-tetramethylhexadecyloxy)-2-furoic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04011334 |
| 出典データセット | uspto-grants-1977_03 |
| ORD ID | ord-fd13263df78048ae968f86bbe42ce2d6 |
| 出典メモ | uspto-grants-1977_03 |